Two new sesquiterpene glycosides from the Lycii Cortex

Thirteen compounds were isolated from the Lycii Cortex by macroporous resin column chromatography, gel column chromatography and semi-preparative high performance liquid chromatography. The structures of the isolated compounds were identified by ultraviolet spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrometry as solavetivone A (1), solavetivone B (2), 9-hydroxy-3-methoxy-6H-pyrido 1, 2-a pyrazin-6-one (3), 5, 5′-di(2-ethyl-hexyloxy)-5, 5′-bifuran (4), bis(2-ethylhexyl) phthalate (5), scopoletin (6), periplogenin (7), 3β, 5β-dihydroxy-14-en-card-20(22)-enolide (8), (7R, 8S)-4-hydroxy-3, 5′-dimethoxy-4′, 7-epoxy-8, 3′-neoligna-9, 9′-diol-4-O-β-D-glucopyranosyl-(1→4)-β-D-glucopy-ranoside (9), 2-carbomethoxy 3-prenyl-1, 4-naphtho hydroquinone-1, 4-di-O-β-glucoside (10), 4-hydroxy-3-methoxyphenyl-β-D-xylopyranosyl (1→6)-O-β-D-glucopyranoside (11), syringic acid (12), vanillic acid (13). Compounds 1 and 2 were new sesquiterpene glycosides with solavetivone skeleton. Compounds 4, 8-10 were isolated from Solanaceae for the first time. The bioactive screening results indicate that compounds 1 and 2 do not exhibit inhibitory effects on NO production; however, they demonstrate weak inhibitory activity against α-glucosidase.