Synthesis and antioxidative activity of flavone derivatives containing 1,2,4-triazole structure

Using bioactive compounds 7-hydroxy flavone, salicylaldehyde, cinnamic acid and 4-amino-5-mercapto-1,2,4-triazoles as starting materials, three new types of flavone derivatives containing 1,2,4-triazole structure were synthesized via different step reactions. These new compounds were characterized by ¹H NMR, ESI-MS, IR and elemental analysis. Their scavenging effects on the superoxide radical (O₂^-·), hydroxyl radical (·OH), DPPH· radical and their total reduction activities were tested. The results showed that all of the compounds possessed some antioxidative activity at the concentration of 0.5 mg·mL^-1, but the scavenging ability of the target compounds was lower than that of the standard compound Vc.