QS Yu, GQ Cai , LG Zhu, . STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE C-2 POSITION OF QUINOLONES BY MMP1 AND CNDO/2J. Acta Pharmaceutica Sinica, 1994, 29(8): 595-598.
Citation:
QS Yu, GQ Cai , LG Zhu, . STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE C-2 POSITION OF QUINOLONES BY MMP1 AND CNDO/2J. Acta Pharmaceutica Sinica, 1994, 29(8): 595-598.
QS Yu, GQ Cai , LG Zhu, . STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE C-2 POSITION OF QUINOLONES BY MMP1 AND CNDO/2J. Acta Pharmaceutica Sinica, 1994, 29(8): 595-598.
Citation:
QS Yu, GQ Cai , LG Zhu, . STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE C-2 POSITION OF QUINOLONES BY MMP1 AND CNDO/2J. Acta Pharmaceutica Sinica, 1994, 29(8): 595-598.
STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE C-2 POSITION OF QUINOLONES BY MMP1 AND CNDO/2
ln this paper ,the structure-activity relationship of C-2 position of quinolones wasstudied by MMP1 and CNDO/2. The coplanarity between carboxyl and keto group is very importantfor biological activities.The correlation between the charge densities of oxygens and nitrogen oncarboxyl ,keto group and nitrogen of N-1 position and biological activities is good.
DownLoad: