LIPOSOLUBLE CONSTITUENTS FROM THE ROOTS OF SCROPHULARIA NINGPOENSIS

AIM: To investigate the liposoluble constituents of the roots of Scrophularia ninpoensis Hemsl.METHODS: The constituens were obtained by solvent extraction and chromatography on silica gel etc.. Their structures were elucidated by chemical and spectroscopic methods (IR, EIMS, ¹HNMR, ¹³CNMR, ¹H-¹H COSY, HMQC, HMBC). RESULTS: Ten compounds were isolated. Among them, compound I and II are new and identified as 3-O-acetyl-2-O-(3-methoxy-4-hydroxycinnamoyl)-α-L-rhamnose and 3-O-acetyl-2-O-(p-hydroxycinnamoyl)-α-L-rhamnose, respectively. The others were identified as known compounds: cinnamic acid (III), 4-hydroxy-3-methoxybenzoic acid (IV), p-methoxycinnamic acid (V), 4-hydroxy-3-methoxycinnamic acid (VI), 5-hydroxymethyl furfural (VII), ursolic acid (VIII), β-sitosterol(IX), β-sitosteryl glucoside (X). CONCLUSION: Compounds IV,V,VII and VIII were isolated from this plant for the first time. Most obtained constituens in ether soluble part of S. ningpoensis were phenolic derivatives.