APPLICATION OF 2D NMR TECHNIQUES IN THE STRUCTURE DETERMINATION OF CHRYSANTHETRIOL

Chrysanthemum indicum L. is a Chinese traditional drug used forantifebrile, detoxication and hypotensive purposes. In continuation of our efforts to searchfor the active principles of this speceies, a new sesquiterpene compound, namedchrysanthetriol was isolated from the more polar fraction of the title plant. Chrysanthetriolis a colorless oil, α_D²⁰-31. 8℃(c 0.3, MeOH). HRMS showed the molecular formula tobe C₁₅H₂₆O₃. The structure and stereochemistry of chrysanthtriol was elucidated as I by theuse of ¹H-¹H COSY, ¹H -¹³C COSY, ¹³H -¹³C COLOC 2D NMR spectroscopy.