Progress in the study of BLyS and APRIL on regulating T cell responses in rheumatoid arthritis

B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation.  However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders.  In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).