Study on the pharmacokinetics of scutellarin in dogs

AimTo determine scutellarin in dog plasma and study the pharmacokinetics of scutellarin in the dog. MethodsScutellarin in plasma of six dogs at different sampling time was determined after single dose of 120 mg iv by RP-HPLC. The mean plasma concentration-time curve was protracted and pharmacokinetic parameters were calculated. ResultsThe concentration-time curve of scutellarin can be fitted to a three-compartment model with the main pharmacokinetic parameters as follows: T_1/2 γ, T_1/2α and T_1/2β were (1.1±0.8) min, (7.0±2.8) min and (52±29) min, respectively, Vc was (880±508) mL, CL was (190±54) mL·min^-1, AUC_0-90 and AUC_0-∞ were (574±134) mg·min·L^-1 and (599±132) mg·min·L^-1 respectively. ConclusionThe concentration of scutellarin in plasma declined rapidly after single dose of 120 mg iv in dogs, and this suggested that the T_1/2 of scutellarin should be taken into account in preparation exploitation and drug administration.