CIRCULAR CHROMATOGRAPHIC SEPARATION OF ALKALOIDAL POISONS BY MEANS OF DOMESTIC FILTER PAPERS

Eight common alkaloidal poisons:Strychnine-Brucine;Cocaine-Atropine;Quinine-Nicotine;& Morphine-Codeine have been separated satisfactorily from each other by circular chromatographic method using domestic filter paper.The method is rather simple and rapid and the separation is as effective as that obtained with Whatman No.1 filter paper.The paper is treated with 5% Sodium dihydrogen citrate,using n-butanol,glacial acetic acid and water(100:30:70)as the deve- loping solvents.The average Rfc values are shown in the following figures: Strychnine…………0.58 Quinine…………0.85 Brucine…………0.69 Nicotine…………0.37 Cocaine…………0.84 Morphine…………0.50 Atropine…………0.79 Codeine…………0.54