XJ Liu, SS Xie, YX Zhang, JL Zhang, Dy Zhang, YL Wang, D Ni, D Li, M Lu , QT Ye, . PREPARATION OF ROTUNDINE-CHITOSAN GELLED GRANULES AND THEIR DRUG-RELEASE TESTSJ. Acta Pharmaceutica Sinica, 1991, 26(10): 782-787.
Citation: XJ Liu, SS Xie, YX Zhang, JL Zhang, Dy Zhang, YL Wang, D Ni, D Li, M Lu , QT Ye, . PREPARATION OF ROTUNDINE-CHITOSAN GELLED GRANULES AND THEIR DRUG-RELEASE TESTSJ. Acta Pharmaceutica Sinica, 1991, 26(10): 782-787.
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PREPARATION OF ROTUNDINE-CHITOSAN GELLED GRANULES AND THEIR DRUG-RELEASE TESTS

    Abstract
  • The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine (56.7%) -chitosan (Mw :5.70×105 degree of deacetylation: 72.4%)gelled granules in an artificial gastroenteric juice (pH 1.0 and 7.2 ) have T50 of 40 and 180 min respectively, and the total release time sustained over 540 min.
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