Study on distribution of safflor yellow A in tissues of mice

AimTo study the distributive character of safflor yellow A in mice. MethodsA RP-HPLC method for the determination of safflor yellow A in tissues was established and applied to determine safflor yellow A in biological samples. ResultsAfter iv injection of Safflor yellow A in mice, the AUC of safflor yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain. ConclusionThe distribution of safflor yellow A in the body is abroad and the speed of its process is swift.