STUDIES ON THE SYNTHESIS AND EXPERIMENTAL THERAPEUTIC EFFECTS OF METAL CHLORIN ON ⁶⁰Co-IRRIDIATED MICE

Pheophorbide a and pyropheophorbide a were prepared by acid degradation of crude chlorophylls isolated from silkworm excrement. Pheophorbide a was further degradated to chlorin e₆ monomethyl ester in alkaline methanol in absence of oxygen.Pure purpurin 18 was directly prepared from alkali degradation of silkworm excrement crude chlorophylls in presence of oxygen. Nine chlorin complexes of Co,Cu and Zn were synthesized for the first time.Preliminary pharmacological tests showed that chlorin e₆ monomethyl ester copper complex(7) could increase survival and prolong the surviving time of ⁶⁰Co-irridiated mice significantly.