Modification of novel oxazolidinone derivatives at C-5 side chain and their antibacterial activities

AimTo modify the C-5 side chains of the oxazolidinone derivatives and evaluate their in vitro antibacterial activities preliminarily. MethodsThe title compounds were synthesized in 9-12 steps with the starting material 3-fluoroaniline and their in vitro antibacterial activities were examined by using Mueller-Hinton broth dilution method. ResultsThirty new compounds were designed and synthesized, in which eighteen novel title compounds were prepared and their structures were confirmed by ^{1H NMR and ESI-MS. Eleven compounds showed antibacterial activities to a certain extent, among them compounds 7a, 9a and 11a displayed promising activity. ConclusionCompounds 7a, 9a and 11a were worth further studying.}