SIMULTANEOUS DETERMINATION OF ASPIRIN AND PHENOBARBITAL IN INFANTILE CO-PHENOBARBITAL POWDER BY DUAL WAVELENGTH K-RATIO SPECTROPHOTOMETRY

Aspirin (Ⅰ) and phenobarbital (Ⅱ) in infantile co-phenobarbital powder were determined simultaneously using dual wavelength K-ratio spectrophotometry. Ⅰ and Ⅱ were analyzed with dual wavelength K-ratio spectrophotometry at 255, 244 and 236 nm. This method showed a mean recovery of 101.3% and a coefficient of variation of 1.6% for (Ⅰ). The mean recovery and CV of Ⅱ were 99.21% and 1.90% (n=6) respectively. The method is simple, rapid and accurate.