SYNTHESIS OF THE NATURALLY OCCURRING PROSTAGLANDIN F_2α

In a previous paper⁽¹⁾ we reported a stereocontrolled synthesis of recemic form of PGF_2α. In this note we outline the synthesis of PGF_2α following essentially the same approach but via a resolution of the intermediate dl-lactone (Ⅰ) and using the l-form (Ⅰa) for the subsequent steps resulting in the naturally occurring PGF_2α. While from the d-lactone (Ⅰb)ent-13-dehydro-15-epi-PGF_2α was obtained as the parallel end product.