SYNTHESIS OF l6-(m-CHLOROPHENOXY)-17, 18, 19, 20-TETRANOR-PROSTAGLANDIN F_2α

A simplified synthetic method for compound (1) was described. Both α,β-unsaturated ketone and y-lactone of (4)b were reduced with Dibal simultaneously to corresponding allylic hydroxy group and γ-lactol in good yield. Without protecting the hydroxy group, the mixture (6) was transformed to the target compound (1) by the known method.