TUMOUR CHEMOTHERAPHY ⅩⅩⅩⅧ SYNTHESIS OF ANALOGUES OF CHLORAMPHENICOL

In view of the tumour inhibitory effect of AT-16, a Schiff's base prepared by condensing 1-p-nitrophenyl-2-aminopropandiol (1, 3) with p-bis (2-chloroethyl) aminobenzaldehyde, several other Schiff's bases were prepared by condensing 1-p-methoxyphenyl2-aminopropane diol (1, 3) with aromatic aldehyde containing N, N, -bis (2-chloroethyl) amino group. Analogys of chloramphenicol in which the nitro group was replaced by methoxy group and the dichloroacetyl group by the moiety of plant growth inhibitors, 2, 4-dichlorophenoxyacetic acid and 2, 4, 5-trichlorophenoxyacetic acid, were also reported.Among these compounds, it was found that the Schiff's base of 4-N, N-bis (2-chloroethyl) amino-3-methyl-benzaldehyde(Ⅳb) possessed a moderate inhibiting action against S-180 in mice.