THE PREPARATION AND BIOACTIVITIES OF CHIRAL ANALOGS OF BAOGONGTENG A

Eight chiral analogs of baogongteng A were prepared from (±)-3α-hydroxy-6β-acetoxytropane by chemical resolution. In myotic or mydriatic tests in rabbits, (-)-3α-paramethyl benzenesulfonyloxy-6β-acetoxytropane showed cholinergic activities, while (+)-3α-benzoyloxy-6β-acetoxytropane and (+)-3α-parachloro benzoyloxy-6β-acetoxytropane showed anticholinergic activities.