A new vomiting animal modelmink

AimTo establish a new, reliable vomiting model in minks. MethodsAdult male minks (Mustela vison) were randomly divided into groups (n=6). Cisplatin, apomorphine, copper sulfate and X-radiation were used to establish vomiting model. Retching and vomiting were observed after the vomiting models were given anti-vomiting agents. After the behavioral experiment, assay of 5-HT in the ileum was performed by immunohistologic method. ResultsCisplatin 7.5 mg·kg^-1 ip, apomorphine 1.6 mg·kg^-1 sc and copper sulfate 40 mg·kg^-1 ig were shown to evoke vomiting. Retching and vomiting were significantly inhibited in ondansetron and metoclopramide pretreated minks (P<0.05, P<0.01). ConclusionAs a new vomiting model, minks may be of great value in studying vomiting mechanism and screening new antiemetic drugs.