EFFECTS OF m-NIFEDIPINE ON LEFT VENTRICULAR DIASTOLIC FUNCTLON AND C^a2+CONTENT OF MYOCARDIAL AND CEREBRAL MITOCHONDRIA AND ARTERY TISSUES IN LEFT VENTRICULAR HYPERTROPHIED RATS

Left ventricular hypertrophy (LVH)was induced by renal hypertension in rats. m-Nifedipine(m-Nif, ig 20 mg·kg^-1·d^-1> for 9 wk)decreased LV weight in the renovascular hypertensive rats(P<0.01).The LV compliance in LVH group was significantly decreased compared with that in sham-operated group.The LV stiffness constant,Ca²⁺ content in left ventricular myocardial and cerebral mitochondrin, aorta,and tail artery were markedly raised.m-Nif could markedly reduce the LV stiffness constant,improve the LV compliance,and decrease the Ca2+content of left ventricular myocardial mitochondria and tissues of artery from LVH rats. These effects of m-Nif were similar to those of nifedipine at the same dosage.