SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTITUMOR ACTIVITY OF DIORGANOTIN(IV) COMPOUNDS OF 4-ACYL-5-PYRAZOLONE

AIM　A series of novel diorganotin (IV) compounds had been synthesized in order to find candidates with antitumor activities by in vitro screening. METHODS　The title compounds were prepared using new β-diketonate donors, 4-acyl-5-pyrazolone as ligands. These new compounds were characterized by elemental analyses, IR spectra, ¹H, ¹³C and ¹¹⁹Sn NMR and screened by several antitumor models in vitro. RESULTS　Nine new compounds formulated as R₂SnL₂ (HL is 4-acyl-5-pyrazolone ligand) were synthesized and their structures were determined. CONCLUSION　Several compounds 3～6 and 9～11 showed different inhibitory effects on HL-60, HCT-8, Bel-7402, BGC-823 and KB cells in vitro and are worthy of further study.