Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin

A water-soluble compound, sodium formononetin-3′-sulfonate with good lipid-lowering and liver-protection activities was synthesized.  It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses.  The solubility of sodium formononetin-3′-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry.  The lipid-lowering and liver-protection activities of sodium formononetin-3′-sulfonate were tested by using rat’s high fat model induce by feeding with high fat food.  The results showed that sodium formononetin-3′-sulfonate not only had      favorable water solubility but also had good lipid-lowering and liver-protection activities.