P Zhu, HX He , SZ Chen, . STIMULATORY EFFECT OF SODIUM DEOXYCHOLATE ON α-ERGOCRYPTINE PRODUCTIVITY OF CLAVICEPS PURPUREA 94002(EKPN94002)J. Acta Pharmaceutica Sinica, 1997, 32(8): 629-632.
Citation: P Zhu, HX He , SZ Chen, . STIMULATORY EFFECT OF SODIUM DEOXYCHOLATE ON α-ERGOCRYPTINE PRODUCTIVITY OF CLAVICEPS PURPUREA 94002(EKPN94002)J. Acta Pharmaceutica Sinica, 1997, 32(8): 629-632.
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STIMULATORY EFFECT OF SODIUM DEOXYCHOLATE ON α-ERGOCRYPTINE PRODUCTIVITY OF CLAVICEPS PURPUREA 94002(EKPN94002)

    Abstract
  • The stimulation of sodium deoxycholate (SDC) on α-ergocryptine production of Claviceps purpurea strain 94002(EKPN94002) was investigated. Preliminary results indicated that SDC, as a stimulator and at appropriate concentrations, could obviously increase the extracellular and the total production levels of the ergot alkaloid. Satisfied results were obtained when 6.0 mg·L-1 of SDC was present in the seed and fermentation media. The possible mechanism was discussed.
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