SYNTHESIS AND BIOACTIVITY OF SUBSTIUTED ADENINES AND ADENOSNES

In order to find an efficient way to synthesize aromatic heterocyclic methvl substi- tuted adenines and adenosines ,using adenine and adenosine as starting materials ,twenty four adenineand adenosine derivatives ,including 9- pyridylmethyl suhtituted adenines(1～7),N⁶ ,9- disubstitutedadenines( 12～17),N⁶- substituted adenines(23～25)and N⁶-subetituted adenosines(18～22)weredesigned and synthesized,three 3- substituted adenines were also synthesized.The structures of thesecompounds were identified with MS,1HNMR and UV spectra,some of them were submitted toelemental analysis and HRMS.All adenosine derivatives and some adenine derivatives synthesizedwere studied for adenosine receptor activity.Compound 18 was shown to be 33 times more active thanadenosine.