PHARMACOKINETICS AND DISP0SITION 0F VINPOCETINE IN RATS

reverse-phaseHPLCmethodfordeterminationofvinpocetineinbiologicalsamples was developed.The method was simple,highly specific and accurate.After iv administrationof vinpocetine in rats , the plasma concentration- time curves of vinpocetine was found to be fitted to atwo-compartment open model. Dosing 5 and l0 mg· kg^-1 vinpocetine in rats,the elimination of thedrug from plasma accorded with linear kinetics and the elimination half-lives were shown to be 1. 76±0.27 h.The volumesofdistribution were 7.30±0.49 L·kg^-1(5 mg·kg^-1)and 6.07±0.67 L·kg^-1(10 mg· kg^-1)respectively.The drug levels were high in the lung, spleen,liver and kidney,moderate in brain,fat and testis and low in heart,muscle and blood. Our results demonstrate thatvinpocetine was eliminated in a rapid rate and distributed widely in the body. The bioavailability ofvinpocetine after ig administration was 5 4.54%in rats.A small amount of unchanged vinpocetinewas detected in urine, feces and bile after iv and ig administration.