STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- <i>N</i><sup>4</sup>′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENE

Q Li; X Shen; HW Shao , YY Xie

Q Li, X Shen, HW Shao , YY Xie, . STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- N4′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENEJ. Acta Pharmaceutica Sinica, 1995, 30(6): 471-475.

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STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- N⁴′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENE

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Abstract

Seventeen compounds having the structure of 2,3-diacetoxy-1,4-bis(3′,5′- dioxo-N⁴′-substituted piperazinyl methyl)benzene were designed and synthesized based on chelation hypothesis. Their antitumor activities on P388 cells,Hep cells and SGC 7901 cells in vitro were tested. Preliminary results showed that compound 4e has potent antitumor effect against P388 cells and.Hep cells in vitro.

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STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- N4′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENE

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STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- N⁴′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENE