STRUCTURES AND PHARMACOLOGICAL ACTIVITIES OF BEESIOSIDES O AND P

AIMTo investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components. METHODSCompounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation. RESULTSTwo novel compounds were isolated and identified as (20S,24S)-15α-acetoxy-16β,24;20,24-diepoxy-9,19-cyclolanostane-3β,25-diol-3-O-β-D-xylopyranoside (I) and (20S,24R)-15α-acetoxy-9,19-cyclolanostane-3β,16β,20,24,25-pentaol-3-O-β-D-xylopyranoside (II), named beesioside O and beesioside P. CONCLUSIONCompounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.