TERBIUM SENSITIZED CHEMILUMINESCENCE OF ENOXACIN

AIM To determine the enoxacin by means of terbium sensitized chemiluminescence in pharmaceutical preparations as well as urine samples. METHODS Through six-way injection valve Ce⁴⁺, H₂SO₃, Tb³⁺ and enoxacin (ENX) standard solutions were injected into the flow system in a certain order, the chemiluminescence signal was detected by weak luminescence analyzer. RESULTS The chemiluminescence intensity was linearly related to the concentration of ENX in the range of 2.0×10^-9-6.0×10^-8 mol·L^-1 with a detection limit of 4.0×10^-10 mol·L^-1 . Relative standard deviation was less than 1.6% (n=11). CONCLUSION It provides a sensitive rapid, simple and accuracy measurement of enoxacin for the pharmacokinetic studies.