CHU TE-HAO, LIU CHEN-KU, YANG CHING-SEN, LU XIAO-TZE AND CHANG CHI-CHIEK, . THE SYNTHESIS OF PRIMAQUINE DIPHOSPHATEJ. Acta Pharmaceutica Sinica, 1956, 4(3): 197-199.
Citation:
CHU TE-HAO, LIU CHEN-KU, YANG CHING-SEN, LU XIAO-TZE AND CHANG CHI-CHIEK, . THE SYNTHESIS OF PRIMAQUINE DIPHOSPHATEJ. Acta Pharmaceutica Sinica, 1956, 4(3): 197-199.
CHU TE-HAO, LIU CHEN-KU, YANG CHING-SEN, LU XIAO-TZE AND CHANG CHI-CHIEK, . THE SYNTHESIS OF PRIMAQUINE DIPHOSPHATEJ. Acta Pharmaceutica Sinica, 1956, 4(3): 197-199.
Citation:
CHU TE-HAO, LIU CHEN-KU, YANG CHING-SEN, LU XIAO-TZE AND CHANG CHI-CHIEK, . THE SYNTHESIS OF PRIMAQUINE DIPHOSPHATEJ. Acta Pharmaceutica Sinica, 1956, 4(3): 197-199.
Primaquine has been synthesized by hydrolysis of the fused product of 6-methoxy-8-aminoquinoline and 4-bromo-1-phthalimidopentane, which has been obtained from 1,4-dibromopentane and potassium phthalimide. The total yield of primaquine diphosphate is 42.5-48.4% (based on the amount of potassium phthalimide used).
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