STUDY ON MITOXANTRONE POLYCYANOACRYLATE NANOSPHERES

The mitoxantrone polybutylcyanoacrylate nanosparticles( DHAQ-PBCA-NP )wereprepared by emulsion polymerization method. The surface charge,drug lodaing,morphology, sizeand size distribution, release characteristics in vitro,stablity and distribution in animals of DHAQ-PR-CA-NP were studied. The results showed that the mean size was d_av=55.23 nm,drug loading was46.77%,embedding ratio was 84.89%. The surface carried negative charge and the release charac-teristics in vitro was in accord with two phases kinetics law. The colloidal solution Of DHAQ-PECA-NPcan undergo boilling for 30 min sterilization. The radiOactivity concentrated mainlv in liver after iv3H-DHAQ-PBCA-NP. The radioactivity in liver tumor was higher than that in the liver tissue.DHAQ-PBCA-NP was observed in parenchymal cell 15 min after iv DHAQ-PBCA-NS.This prepara-tion seems to have important value for increasing the anti-liver tumor effect and decreasing the toxicityof DHAQ.