SYNTHESIS OF SARMENTOSIN

Chu Guohua, Zhou Qiting , Bai Donglu, . SYNTHESIS OF SARMENTOSINJ. Acta Pharmaceutica Sinica, 1999, 34(1): 34-38.

Citation:

Chu Guohua, Zhou Qiting , Bai Donglu, . SYNTHESIS OF SARMENTOSINJ. Acta Pharmaceutica Sinica, 1999, 34(1): 34-38.

Citation:

Chu Guohua, Zhou Qiting , Bai Donglu, . SYNTHESIS OF SARMENTOSINJ. Acta Pharmaceutica Sinica, 1999, 34(1): 34-38.

Abstract

AIM: The synthesis of sarmentosin. METHODS: Condensation of butane-1,2,4-triol-1,2-acetonide(3) with α-D-glucopyranosyl bromide tetraacetate in the presence of Ag2O and molecular sieves gave the desired β-glucoside 4, which was transformed into sarmentosin via a reaction sequence of 7 steps. RESULTS: The overall yield is 5.8%. CONCLUSION: The first synthesis of sarmentosin(1), a potent natural GPT lowering agent, was achieved.

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