Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives

AimTo design and synthesize new compounds of prandial glucose regulator with more simple structure. MethodsThe target compounds were synthesized from diethyl succinate and benzaldehyde or 4-fluorobenzaldehyde by four-step reactions. Thus 18 compounds were synthesized. Their structures were comfirmed by NMR, MS and IR. ResultsSeventeen compounds had different hypoglycemic activeity in mice, among them, 9 compounds had higher hypoglycemic activity and 6 compounds had character of prandial glucose regulator. ConclusionPart of the compounds have higher hypoglycemic activity deserve to be further investigated.