SYNTHESIS OF ST-1435 DERIVATIVES AS CONTRACEPTIVE FOR LACTATING WOMEN

Four new ST- 1435 derivatives 4～ 7 were synthesized. Both 4 and 5 are mixture of Z- and E- isomers. 4 was separated into Z- and E- isomers by spinning TLC. Their binding ability to progesterone receptor was examined and found to be less than ST- 1435.