XU Mao-li, YE Ding-yi, ZHANG Yuan-lang , LEI Xing-han, . THE CIS-ISOMER OF ANTISHISTOSOMAL DRUG FURAPROMIDEJ. Acta Pharmaceutica Sinica, 1982, 17(12): 905-908.
Citation: XU Mao-li, YE Ding-yi, ZHANG Yuan-lang , LEI Xing-han, . THE CIS-ISOMER OF ANTISHISTOSOMAL DRUG FURAPROMIDEJ. Acta Pharmaceutica Sinica, 1982, 17(12): 905-908.
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THE CIS-ISOMER OF ANTISHISTOSOMAL DRUG FURAPROMIDE

    Abstract
  • Nitration of cis-β-(2-furyl) acrylic acid afforded the corresponding cis-β-(5-nitro-furyl), acrylic acid. It was readily converted to cis-β-(5-nitro-2-furyl)-N-isopropyl-acrylamide by amination with isopropylamine through the mixed anhydride method.The biological activity of this cis-isomer was examined in laboratory animals against experimental schistosomiasis and was shown to possess activity similar to that already reported for the trans-isomer.
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