SYNTHESIS AND VASODILATING ACTIVITY OF BENZAMIDE AND CINNAMIDE DERIVATIVES

AIM: To search for compounds having strong vasodilating effect. METHODS: The mixed anhydride method was used. RESULTS: Twenty benzamides(I_1～12) and cinnamides(II_1～8) were designed and synthesized. CONCLUSION: All synthesized amides were submitted to pharmacological screening and 0.1 μmol.L^-1 (10-7mol.L^-1) noradrenaline induced contraction of rat aortic strip was taken as criterion. Compound I₅ was shown to be a potent potassium channel activator. Compound II₈ exhibited calcium antagonistic activity and showed potent vasodilating activity.