Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation

Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound.  Six ferulic acid derivatives were designed and synthesized based on bioisosterism.  Their structures were characterized by IR, ¹H NMR, ¹³C NMR and mass spectra.  In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.