FH Qiu, L Liu, Y Luo , YQ Lu, . A DOUBLE COLUMN DOUBLE pH SOLID PHAES EXTRACTION AND CAPILLARY GC/FID METHOD FOR RAPID SIMULTANEOUS DETERMINATION OF ACIDIC AND BASIC DRUGS IN HUMAN PLASMAJ. Acta Pharmaceutica Sinica, 1996, 31(3): 205-208.
Citation: FH Qiu, L Liu, Y Luo , YQ Lu, . A DOUBLE COLUMN DOUBLE pH SOLID PHAES EXTRACTION AND CAPILLARY GC/FID METHOD FOR RAPID SIMULTANEOUS DETERMINATION OF ACIDIC AND BASIC DRUGS IN HUMAN PLASMAJ. Acta Pharmaceutica Sinica, 1996, 31(3): 205-208.
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A DOUBLE COLUMN DOUBLE pH SOLID PHAES EXTRACTION AND CAPILLARY GC/FID METHOD FOR RAPID SIMULTANEOUS DETERMINATION OF ACIDIC AND BASIC DRUGS IN HUMAN PLASMA

    Abstract
  • A capillary gas chromatographic method for the rapid simultaneous iden tificationand quantitation of acidic and basic drugs in human plasma is presented,A special double column solidphase extraction device was designed ,in which two X-5 resin columns can extract drugs at differentpH,The detection limits for acidic and hasic drugs can reach 0.5μg·ml-1,while the time needed isonly half of that when using commercial solid phase extraction cartridges.
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