EXPRESSION OF INTERLEUKIN-6 IN DELAYED TYPE　HYPERSENSITIVITY AND INHIBITION EFFECTS OF RESVERATROL ON INTERLEUKIN-6 BIOSYNTHESIS

AIM: To study the effects of resveratrol on Interleukin 6 (IL-6) biosynthesis, observe the action of IL-6 in the process of immunoinflammation and investigate the mechanism of the antiinflammation effects of resveratrol. METHODS: Immuno-histochemistry was used to detect the levels of IL-6 in delayed type hypersensitivity induced by DNFB(2,4-Dinitrofluorobenzene). RESULTS: In the mouse models of inflammation of delayed type hypersensitivity induced by DNFB, resveratrol was shown to significantly(30%) inhibit the inflammatory response at the dose of 50 mg*kg^-1(sc), and resveratrol, at the doses of 50 and 100 mg*kg^-1(sc) inhibited production of IL-6. CONCLUSION: Resveratrol is a potent antiinflammatory agent and there is IL-6 expression in the mouse model of delayed type hypersensitivity induced by DNFB. The mechanism of actions of resveratrol on antiinflammation may be related with the inhibition of IL-6 biosynthesis.