STUDIES ON ANTITUMOUR DRUGS Ⅸ. SOME PHARMACOLOGICAL ACTIONS OF N-FORMYLSARCOLYSINE

In earlier communications, we reported that N-Formylsarcolysine (N-F) was an effec- tive antitumour agent with low toxicity.The present paper is a report on some phar- macological actions of N-F. After oral administration of N-F at 25-150 mg/kg/day to mice for 10 days, the drug did not decrease the swimming time, nor did it prolong the pentobarbital sleeping time.When mice were injected intraperitoneally with 10-20 mg/kg of N-F daily for 10 days, there was no prolongation of pentobarbital sleeping time.Intraperitoneal injec- tion of N-F at 10 mg/kg/day to rats for 10 days produced no marked change in diuresis, the contents of the adrenal ascorbic acid, and the permeability of the capillaries.In- travenous injection of N-F 10-40 mg/kg to anaesthetized rabbits did not alter the blood pressure. When rats were injected intraperitoneally with N-F at 20 mg/kg for 10 days, an inhibition of diuresis was observed beginning 5 days after the treatment. However, the diuretic function of rats became normal three days after cessation of N-F. Two hours after intraperitoneal injection of 80 mg/kg of N-F to rats the content of the adrenal ascorbic acid was significantly reduced and the permeability of the capillary increased markedly.