JM Pei, SS Zhou, GB Niu, MZ Zhu , YM Zang, . EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITSJ. Acta Pharmaceutica Sinica, 1992, 27(10): 721-724.
Citation: JM Pei, SS Zhou, GB Niu, MZ Zhu , YM Zang, . EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITSJ. Acta Pharmaceutica Sinica, 1992, 27(10): 721-724.
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EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITS

    Abstract
  • The effects of potassium ion Channel blocker TEA and calcium ion channel blokerverapamil on effective refractory period (ERP) of ischemic ventricular muscle were studied in rabbits.The results showed that ERP of the ventricular muscle in central ischemic zone (CIZ) and border is-chemic zone (BIZ) wete shortened, respectively, at 10 min and 30 min after coronary occlusion(P<0. 01). The changes of ERP in TEA--treated and verapamil--treated rabbits after coronary oc-clusion were found to be significantly less than those in untreated rabbits. The results suggest that TEAand verapamil alleviated the degree of ERP shortening after coronary occlusion and may exhibit protec-tive effects on the ischemic myocardium.
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