PROTECTIVE EFFECTS OF FURYL-DIHYDROPYRIDINE I ON ISCHEMIC MYOCARDIUM IN ISOLATED RABBIT HEARTS

A recirculating nonpulsatile perfusion circuit was used in isolated rabbit hearts. Furyl-dihydropyridine Ⅰ( 2, 6-dimethyl-4-furyl-1, 4-dihydropyridine-3, 5-dicarboxylate)20μmol/L was shown to inhibit the release of creatine phosphokinase (CPK) and α-hydroxybutyrate dehydrogenase (HBD) from myocardium, decrease myocardial calcium and sodium contents by 5.3±1.1μmol/g dry weitght (P<0.01, n=6) and 1.50±0.17mmol/g dry weight (P<0.05, n=6) from 8.3±1.1μmol/g dry weight and 1.96±0.32 mmol/g dry weight respectively. It was alse found to reduce coronary resistance and increase coronary flow of the ischemic myocardium, and prevent ischemic arrhythmia, thereby limit myocardial injury during regional ischemia in isolated rabbit hearts.