MODIFICATION AT THE 11 POSITION OF 18-METHYL ESTRADIOL-3-METHYL ETHER AND STUDIES ON STRUCTURE-ANTIFERTILITY RELATIONSHIP

In a search for new estrogenic antifertility drugs, six 11-substituted compounds (11α-hydroxyl (5), 11α-methoxyl (12),11βt-hydroxyl (14), 11β-methoxyl (16), 9β-H-11α-hydroxyl (19) and 9β-H-11α-methoxyl (21)) were synthesized from 13-ethyl-3-methoxy-gena-1,3,5 (10), 8-tetraene-17-one (1). The .synthetic route was shown in diagram. Among these compounds, (12),(16), (19) and (21) have not been cited in the literature. Their structures and configurations were confirmed by spectral analysis and chemical transformation.