SYNTHESIS OF 6- OR 7-STYRYLCOUMARIN DERIVATIVES AND THEIR ANTITUMOR ACTIVITIES

AIM: A series of styrylcoumarin derivatives had been designed in order to find compounds of antitumor activities by screening in vitro. METHODS: Title compounds (I1～III6) were synthesized by phase-transfer Wittig reaction and screened by several antitumor models in vitro. RESULTS: Thirty new compounds of 6- or 7-styrylcoumarin(I₁～III₆) were synthesized and their configurations were determined. Seven compounds(I_2，I₄，II₂，II_2c，III_1a，III_2a and III_5a) showed different inhibitory effects on L-1210, HL-60, HCT-8, KB and Bel-7402 cell lines in vitro. CONCLUSION: Some 6- or 7-styrylcoumarin derivatives showed antitumor activities and is worth further study.