STUDIES ON THE SYNTHESIS OF dl-LIGUSTIPHENOL AND ITS ANALOGUES

S-(-)-Ligustiphenol is a new sesquiterpene with antiinflammatory and immunosuppressive activities. In order to study its pharmacological activities, the total synthesis of its racemat was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction, Aldol condensation, etc.The target compound was characterized by comparing its ¹HNMR, MS and IR spectra with natural (-)-ligustiphenol. In order to study the structureactivity relationships of ligustiphenol, its five analogues were designed and synthesized. The pharmacological screening of these analogues has been performed.