EFFECT OF PANAXATRIOL SAPONINS ISOLATED FROM PANAX NOTOGINSENG(PTS)ON MYOCARDIAL ISCHEMIC ARRHYTHMIA IN MICE AND RATS

PTS, one of the major effective components of Panax notoginseng was found to exertremarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arry-thmias in rats. PTS also reduced the size of myocardial infarct. For iv CaCl₂-Ach induced atrial fibr-illation and/or flutter in mice, PTS produced a significant protective effect. In addition, PTS showedan action of prolonging the life under the condition of normobaric hypoxia.