DEVELOPMENT OF PENTYLENETETRAZOL KINDLING MODEL

An ideal animal model of chemical kindling mimicking human epilepsy was developed in 28 day-old rats. Rats were given pentylenetetrazol (PTZ) 30 mg/kg, ip, once per day for 28 consecutive days; after stopping treatment for one week, the rats were retreated using the same dose of PTZ until reaching the kindled criterion. The kindled rate was 74%. The behavioral seizure and EEG discharges were synchronized. All kindled rats still kept their high seizure state after the experiments.