Effects of the effective components group of Xiaoshuantongluo formula on rat acute blood stasis model

Effects of the effective components group of Xiaoshuantongluo formula (XECG) on rat acute blood stasis model were studied under the guidance of the concept of effective components group.  Rat acute blood stasis model was induced by subcutaneous injection of epinephrine combined with ice water bath.  Hemorheology indices such as whole blood viscosity, plasma viscosity, erythrocyte aggregation index and platelet aggregation rate; coagulation parameters including PT, APTT, TT and FIB; 6-keto-PGF_1α , TXB₂ and D-dimer levels were determined to evaluate the effects of XECG.  The results showed that XECG significantly reduced ADP-induced platelet aggregation, but showed little influence on the whole blood viscosity, plasma viscosity and erythrocyte aggregation rate.  XECG extended PT and TT slightly, but had no effects on APTT and FIB content.  D-dimer levels significantly decreased after administration of XECG with a little decrease of TXB₂, but the content of 6-keto-PGF_1α did not change significantly.  The results suggest that the role of XECG of anti-aggregation is more prominent.