Isolation and identification of two new epimer from the mother liquid of megestrol acetate

AimTo study the impurity in the drug megestrol acetate. MethodsChromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis. ResultsTwo new epimers were isolated from the mother liquid of the drug megestrol acetate. ConclusionThese new epimers were identified as 17α-acetoxy-2β,6α-dimethylprega-4-ene-3,20-dione (1) and 17α-acetoxy-2α,6α-dimethylprega-4-ene-3,20-dione (2).