THE REDUCTION OF PROSTAGLANDIN INTERMEDIATE WITH DIISOBUTYLALUMINIUM HYDRIDE

Enonelactone (1b), a Prostaglandin intermediate, was reduced with diisobutylaluminium hydride in one-step in good yield to give (S) and (R) allylic hydrolactol(3d), through the Wittig reaction and then were converted to prostaglandin F_2α and 15(R)prostaglandin F_2α respectively after removal of the protecting group. Lithium diisopropylamine (LDA) has been used as base in place of dimsylsodium for the preparation of Wittig reagent and gave satisfactory result in Wittig reaction.