THE PHARMACOLOGY OF SABIANINE A Ⅰ.THE ANALGESIC AND ANTIPHLOGISTIC ACTIONS AND ACUTE TOXICITY

Intraperitoneal injection of Sabianine,A an alkaloid isolated from the stem of Sabia japonica (Qingfengdung),at A dose of 50 mg/kg in mice raised the pain threshold significantly.The po- tency ratio of Sabianine A and morphine hydrochloride was about 1:2.5. In addition,Sabianine a administered intraperitoneally at a dosage of 60 mg/kg not only lessened the severity of the swelling of the ankle joint of the rats hind leg caused by the injection of formalin or egg-white,but also rendered the swelling of the ankle joint disappear more rapidly. The LD₅₀ of Sabianine for mice A administered intraperitoneally was 285±29 mg/kg.