G3BP: a promising target for cancer therapy

G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling.  G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation.  G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA    metabolism.  It has been shown to be over-expressed in a number of human malignancies and has a close    relationship with tumor invasion and metastasis.  Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.